Alberto Pappalardo, MD

Associate Research Scientist, Department of Dermatology
Columbia University Irving Medical Center

Biography

Dr. Pappalardo is an Associate Research Scientist in the Department of Dermatology at Columbia University Irving Medical Center. His research focuses on developing advanced engineered human skin and multi-organ in vitro systems, with applications in disease modeling, cell therapy, wound healing, and tissue regeneration.  In addition to applying these cell-based approaches to healthy human skin across the lifespan, he also has a special interest in rare genetic skin disorders, in particular, recessive dystrophic epidermolysis bullosa.  In the context of cellular senescence, his recent work demonstrated that depletion of senescent dermal papilla cells can partially restore hair follicle inductive capacity.

As a founding member of the NIH Cellular Senescence Network (SenNet) consortium site at Columbia University, he leads the development of microphysiological platforms to model intrinsic and extrinsic skin senescence, for the identification new biomarkers and evaluation of novel senolytic drugs.